{"id":7318,"date":"2023-01-20T12:55:34","date_gmt":"2023-01-20T09:55:34","guid":{"rendered":"https:\/\/urbancare.clinic\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab\/"},"modified":"2023-01-20T12:55:34","modified_gmt":"2023-01-20T09:55:34","slug":"hiv-impfstoff-in-der-spatphase-der-studie-scheitert-an-der-verlangerung-des-wartens-auf-eine-wirksame-impfung","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab\/","title":{"rendered":"HIV-Impfstoff in der Sp\u00e4tphase der Studie scheitert, was das Warten auf eine wirksame Impfung verl\u00e4ngert"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Der einzige HIV-Impfstoff in einem sp\u00e4ten Versuch ist gescheitert. Die d\u00fcsteren Nachrichten sind ein D\u00e4mpfer f\u00fcr konzertierte HIV-Bek\u00e4mpfungsbem\u00fchungen.&nbsp;<\/p>\n<p>Die Ank\u00fcndigung wurde von beteiligten Forschern am Mittwoch gemacht. <a href=\"https:\/\/www.nbcnews.com\/nbc-out\/out-health-and-wellness\/another-major-hiv-vaccine-trial-fails-rcna66324\" rel=\"nofollow noopener\" target=\"_blank\">NBCNews<\/a> gemeldet. Der Impfstoffversuch mit dem Produkt namens \u201eMosaico\u201c war eine \u00f6ffentlich-private Partnerschaft zwischen der US-Regierung und dem Pharmariesen Janssen.<\/p>\n<p>Die im Jahr 2019 gestartete Studie wurde in acht L\u00e4ndern in Europa und Amerika, einschlie\u00dflich den USA, durchgef\u00fchrt. Fast 3.900 M\u00e4nner, die Sex mit M\u00e4nnern und Transgender-Personen haben, wurden f\u00fcr die Studie rekrutiert und galten alle als einem erh\u00f6hten HIV-Risiko.<\/p>\n<p>Ein unabh\u00e4ngiges Daten- und Sicherheits\u00fcberwachungsgremium untersuchte die Ergebnisse der Studie und stellte keinen Zusammenhang zwischen dem Impfstoff und der HIV-Infektionsrate fest. Daher beschlossen die Forscher, ihre Arbeit einzustellen.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>\u201eEs ist offensichtlich entt\u00e4uschend\u201c, sagte Dr. Anthony Fauci, ehemaliger Leiter des Nationalen Instituts f\u00fcr Allergien und Infektionskrankheiten (NIAID) und integraler Partner der Studie, laut der Nachrichtenagentur. Er f\u00fcgte hinzu: \u201eEs gibt viele andere Ans\u00e4tze\u201c im betrachteten Bereich der HIV-Impfstoffforschung, die er f\u00fcr vielversprechend h\u00e4lt.<\/p>\n<p>\u201eIch glaube nicht, dass die Menschen den HIV-Impfstoff aufgeben sollten\u201c, sagte Fauci.<\/p>\n<p>Nach Ansicht der Experten ist dieser Misserfolg nicht \u00fcberraschend. Ein \u00e4hnlicher Impfstoff in einer separaten klinischen Studie namens Imbokodo scheiterte ebenfalls&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/hiv-vaccine-candidate-does-not-sufficiently-protect-women-against-hiv-infection\" rel=\"nofollow noopener\" target=\"_blank\">im August 2021<\/a>. Der Impfstoff wurde bei Frauen in Afrika getestet. Laut einem Sprecher der Agentur hatte NIAID insgesamt $56 Millionen f\u00fcr die beiden Studien ausgegeben.<\/p>\n<p>Die Impfstoffe in beiden Studien verwendeten ein Erk\u00e4ltungsvirus zur Abgabe von Mosaik-Immunogenen. Man ging davon aus, dass das Immunogen eine robuste Immunantwort ausl\u00f6sen w\u00fcrde, da es genetisches Material aus einer Mischung weltweit verbreiteter HIV-St\u00e4mme enthielt.&nbsp;<a href=\"https:\/\/www.nih.gov\/news-events\/news-releases\/nih-partners-launch-hiv-vaccine-efficacy-study\" rel=\"nofollow noopener\" target=\"_blank\">nach Angaben der National Institutes of Health<\/a>. Mosaico war insofern einen Schritt voraus, als es ein zus\u00e4tzliches Element zur Verst\u00e4rkung der Immunantwort enthielt.&nbsp;<\/p>\n<p>In der Studie \u201eMosaico\u201c erhielten Teilnehmer im Alter zwischen 18 und 60 Jahren \u00fcber ein Jahr hinweg vier Injektionen. Nach der Analyse wird das \u00dcberwachungsgremium <a href=\"https:\/\/newatlas.com\/medical\/large-phase-3-hiv-vaccine-trial-fails-nih\/\" rel=\"nofollow noopener\" target=\"_blank\">keinen Unterschied festgestellt<\/a> in der HIV-Infektionsrate zwischen den beiden Gruppen \u2013 Impfstoff und Placebo.<\/p>\n<p>Die Tatsache, dass der Mosaico-Impfstoff sogenannte nicht neutralisierende Antik\u00f6rper gegen HIV und nicht neutralisierende Antik\u00f6rper hervorrief, erwies sich als seine Einschr\u00e4nkung, bemerkte Fauci.<\/p>\n<p>\u201eEs wird klar\u201c, sagte er, \u201edass Impfstoffe, die keine neutralisierenden Antik\u00f6rper induzieren, nicht wirksam gegen HIV sind.\u201c<\/p>\n<p>Das Scheitern des Prozesses sei eine \u201estarke Erinnerung daran, wie schwer fassbar ein \u2026 ist.\u201c <a href=\"https:\/\/www.medicaldaily.com\/common-anti-viral-drugs-can-stop-hiv-transmission-mother-child-467581\">HIV<\/a> \u201eImpfung ist wirklich wichtig und warum diese Art der Forschung weiterhin wichtig ist\u201c, sagte Jennifer Kates, Direktorin f\u00fcr globale Gesundheits- und HIV-Politik bei der Kaiser Family Foundation.<\/p>\n<p>\u201eGl\u00fccklicherweise gibt es bereits eine Reihe hochwirksamer HIV-Pr\u00e4ventionsma\u00dfnahmen\u201c, f\u00fcgte Kates hinzu. \u201eDie Herausforderung besteht darin, sie auszuweiten, um alle gef\u00e4hrdeten Personen zu erreichen.\u201c&nbsp;<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/hiv-vaccine-late-stage-trial-fails-extending-wait-effective-jab-467815?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Das Scheitern des Versuchs sei eine \u201edeutliche Erinnerung daran, wie schwer ein HIV-Impfstoff wirklich zu finden ist und warum diese Art der Forschung weiterhin wichtig ist\u201c, sagte Jennifer Kates, Direktorin f\u00fcr globale Gesundheits- und HIV-Politik bei der Kaiser Family Foundation.<\/p>","protected":false},"author":2,"featured_media":7319,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/hiv-vaccine-in-late-stage-trial-fails-extending-wait-for-effective-jab.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7318","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>HIV Vaccine In Late Stage Trial Fails, Extending Wait For Effective Jab - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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