{"id":7302,"date":"2023-01-16T12:39:44","date_gmt":"2023-01-16T09:39:44","guid":{"rendered":"https:\/\/urbancare.clinic\/chemicals-in-moms-vagina-may-be-associated-with-preterm-birth-study\/"},"modified":"2023-01-16T12:39:44","modified_gmt":"2023-01-16T09:39:44","slug":"chemikalien-in-der-vagina-der-mutter-konnen-mit-fruhgeburten-in-verbindung-gebracht-werden","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/chemicals-in-moms-vagina-may-be-associated-with-preterm-birth-study\/","title":{"rendered":"Chemikalien in der Vagina der Mutter k\u00f6nnen mit Fr\u00fchgeburten in Zusammenhang stehen: Studie"},"content":{"rendered":"
<\/div>\n

K\u00f6nnen Umwelteinfl\u00fcsse schwangere Frauen beeintr\u00e4chtigen? Forscher haben herausgefunden, dass Chemikalien in der Vagina einer Mutter mit einer spontanen Fr\u00fchgeburt in Verbindung gebracht werden k\u00f6nnen.<\/p>\n

F\u00fcr ihr Studium, ver\u00f6ffentlicht<\/a> In Nature Microbiology untersuchte ein Forscherteam das Vaginalmetabolom des zweiten Trimesters von 232 schwangeren Frauen. Das Metabolom ist im Wesentlichen das \u201eKomplett-Set<\/a>\u201eder kleinen Molek\u00fcle in einer Zelle oder einem Organismus.<\/p>\n

\u201eDas Metabolom kann als funktionelle Anzeige des \u00d6kosystems als Ganzes betrachtet werden\u201c, sagte der Co-Leiter der Studie, Tal Korem vom Columbia University Irving Medical Center (CIUMC), erkl\u00e4rt<\/a> in der Hochschulmitteilung. \u201eMikrobiom-Profiling kann uns sagen, wer die Mikroben sind; Die Metabolomik bringt uns n\u00e4her an das Verst\u00e4ndnis, was die Mikroben tun.\u201c<\/p>\n

Vaginale Mikroben und Metaboliten wurden damit in Verbindung gebracht Schwangerschaftskomplikationen<\/a>, einschlie\u00dflich Fr\u00fchgeburt<\/a> \u2014 die Situation, in der ein Baby vor der 37. Schwangerschaftswoche geboren wird.<\/p>\n

<\/div>\n

Die Forscher stellten fest, dass Fr\u00fchgeburten die \u201eh\u00e4ufigste Todesursache\u201c bei Neugeborenen seien. Und diejenigen, die \u00fcberleben, k\u00f6nnen auch enden sich entwickelnde Probleme<\/a> wie Atemprobleme, Entwicklungsverz\u00f6gerung, H\u00f6rprobleme oder Zerebralparese.<\/p>\n

Spontane Fr\u00fchgeburten (spontane Fr\u00fchgeburten, sPTB) hingegen sind Fr\u00fchgeburten, die nicht medizinisch herbeigef\u00fchrt werden und etwa zwei Drittel aller PTBs ausmachen. Es gilt als \u201eeine der Hauptursachen f\u00fcr Morbidit\u00e4t und Mortalit\u00e4t bei M\u00fcttern und Neugeborenen\u201c.<\/p>\n

\u201eFr\u00fchere Untersuchungen deuten darauf hin, dass vaginale Mikroben und Metaboliten an sPTB beteiligt sein k\u00f6nnten\u201c, schrieben die Forscher.<\/p>\n

Ein \u201eklarer Konsens\u201c \u00fcber den genauen Zusammenhang zwischen den beiden Faktoren blieb jedoch weitgehend unerreichbar.<\/p>\n

Von den 232 Frauen in der Studie brachten 80 eine Fr\u00fchgeburt zur Welt.<\/p>\n

Die Forscher fanden \u201evielfache Zusammenh\u00e4nge\u201c zwischen den Vaginalmetaboliten der M\u00fctter und einer eventuellen Fr\u00fchgeburt. Laut CUIMC waren die multiplen Metaboliten bei ihnen tats\u00e4chlich h\u00f6her als bei denen, die zur vollen Entbindung kamen. Bemerkenswerterweise waren mehrere Metaboliten \u201emit starker Assoziation mit sPTB\u201c exogen oder stammten aus externen Quellen.<\/p>\n

\u201eDazu geh\u00f6ren Diethanolamin (DEA), Ethyl-Beta-Glucosid, Tartrat und Ethylendiamintetraessigs\u00e4ure\u201c, sagte Korem laut CUIMC. \u201eObwohl wir die Quelle dieser Xenobiotika bei unseren Teilnehmern nicht identifiziert haben, konnten sie alle in Kosmetika und Hygieneprodukten gefunden werden.\u201c<\/p>\n

Beispielsweise hat DEA \u201ekeine bekannte nat\u00fcrliche Quelle\u201c und Frauen im geb\u00e4rf\u00e4higen Alter sollen ihm \u201estark ausgesetzt\u201c sein. Ethylglucosid hingegen ist in Produkten enthalten, die Alkohol enthalten. Beide sollen \u201eVorprodukte bzw. Inhaltsstoffe in Hygiene- und Kosmetikprodukten\u201c sein.<\/p>\n

\u201eDie Tatsache, dass alle in Hygiene- und Kosmetikprodukten dokumentiert sind, gibt Anlass zur Sorge, dass einige dieser Produkte das Risiko einer sPTB erh\u00f6hen k\u00f6nnten\u201c, schrieben die Forscher. \u201eUnsere Ergebnisse stimmen mit j\u00fcngsten Studien \u00fcberein, die Bedenken hinsichtlich der Umweltbelastung in der Schwangerschaft aufkommen lassen, und identifizieren diese Chemikalien im Fortpflanzungstrakt.\u201c<\/p>\n

Die Forscher entwickelten au\u00dferdem einen Algorithmus, der Fr\u00fchgeburten \u201emit guter Genauigkeit\u201c vorhersagen konnte. Laut CUIMC muss es jedoch noch verbessert und weiter validiert werden, bevor es im klinischen Umfeld eingesetzt werden kann.<\/p>\n

Insgesamt zeigten die Forscher das Potenzial solcher Metabolitentests zur Vorhersage von sPTB und hoben auch einige potenzielle externe Expositionen hervor, die Risikofaktoren daf\u00fcr sein k\u00f6nnten. Es w\u00e4re lohnenswert, die m\u00f6gliche Quelle der Exposition genauer zu untersuchen und zu pr\u00fcfen, ob sie tats\u00e4chlich zu Fr\u00fchgeburten f\u00fchrt, sagte Korem.<\/p>\n

\u201eDie gute Nachricht ist, dass es m\u00f6glich sein k\u00f6nnte, diese potenziell sch\u00e4dlichen Belastungen zu begrenzen, wenn diese Chemikalien schuld sind\u201c, f\u00fcgte er hinzu.<\/p>\n

Medizinische t\u00e4gliche Quelle<\/a><\/p>\n

","protected":false},"excerpt":{"rendered":"

Vaginale Mikroben und Metaboliten werden mit Schwangerschaftskomplikationen in Verbindung gebracht, einschlie\u00dflich Fr\u00fchgeburten \u2013 der Situation, in der ein Baby vor der 37. Schwangerschaftswoche zur Welt kommt.<\/p>","protected":false},"author":2,"featured_media":7303,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2023\/01\/chemicals-in-moms-vagina-may-be-associated-with-preterm-birth-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7302","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"\nChemicals In Mom's Vagina May Be Associated With Preterm Birth: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/chemikalien-in-der-vagina-der-mutter-konnen-mit-fruhgeburten-in-verbindung-gebracht-werden\/\" \/>\n<meta property=\"og:locale\" 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