{"id":7081,"date":"2022-12-29T13:12:32","date_gmt":"2022-12-29T10:12:32","guid":{"rendered":"https:\/\/www.medicaldaily.com\/scientists-develop-blood-test-alzheimers-diagnosis-467657"},"modified":"2022-12-29T13:12:32","modified_gmt":"2022-12-29T10:12:32","slug":"wissenschaftler-entwickeln-bluttest-zur-alzheimer-diagnose","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/scientists-develop-blood-test-for-alzheimers-diagnosis\/","title":{"rendered":"Wissenschaftler entwickeln Bluttest zur Alzheimer-Diagnose"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/scientists-develop-blood-test-for-alzheimers-diagnosis.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Wissenschaftler haben einen radikalen Bluttest entwickelt, um die Alzheimer-Krankheit zu erkennen. Berichten zufolge hat dieser Bluttest einen Vorteil gegen\u00fcber anderen Bluttests auf diesem Gebiet.<\/p>\n<p>Alzheimer ist eine neurodegenerative Erkrankung und die h\u00e4ufigste Form der Demenz. Ihre Diagnose ist jedoch eine Herausforderung, insbesondere zu Beginn der Krankheit.<\/p>\n<p>F\u00fcr eine erfolgreiche Diagnose wird der Nachweis von drei unterschiedlichen Markern empfohlen. Dazu geh\u00f6ren eine \u00fcberm\u00e4\u00dfige Ansammlung von Amyloid- und Tau-Proteinen sowie ein langsamer und fortschreitender Verlust neuronaler Zellen in bestimmten Regionen des Gehirns.<\/p>\n<p>Derzeit erfordert die Diagnose der Alzheimer-Krankheit eine teure Bildgebung des Gehirns und eine schmerzhafte Lumbalpunktion <a href=\"https:\/\/www.theguardian.com\/society\/2022\/dec\/28\/scientists-develop-blood-test-for-alzheimers-disease\" rel=\"nofollow noopener\" target=\"_blank\">Der W\u00e4chter<\/a>. Daher liegt die Notwendigkeit einer einfacheren Bluttestdiagnose auf der Hand.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>Die Bildgebung des Gehirns ist nicht nur teuer, sondern erfordert auch lange Wartezeiten f\u00fcr die Terminplanung.<\/p>\n<p>\u201eViele Patienten, selbst in den USA, haben keinen Zugang zu MRT- und PET-Scannern. \u201eZug\u00e4nglichkeit ist ein gro\u00dfes Thema\u201c, sagt Prof. Thomas Karikari von der University of Pittsburgh in Pennsylvania, USA, Mitautor der in der Zeitschrift ver\u00f6ffentlichten Studie <a href=\"https:\/\/academic.oup.com\/brain\/advance-article\/doi\/10.1093\/brain\/awac407\/6960988?login=false\" rel=\"nofollow noopener\" target=\"_blank\">Gehirn<\/a>, sagte.<\/p>\n<p>Die Lumbalpunktion ist ein sehr schmerzhafter Eingriff, bei dem Gehirn-R\u00fcckenmarks-Fl\u00fcssigkeit (CSF) aus dem R\u00fcckenmark entnommen wird. Nach dem Eingriff kann es sogar zu Kopf- oder R\u00fcckenschmerzen kommen.<\/p>\n<p>Blutuntersuchungen sind nicht nur schmerzlos und leicht verf\u00fcgbar, sondern helfen auch bei der Fr\u00fcherkennung der Krankheit, was wiederum zu einem fr\u00fchen Beginn der Behandlung f\u00fchrt.<\/p>\n<p>\u201eEin Bluttest ist billiger, sicherer und einfacher durchzuf\u00fchren und kann das klinische Vertrauen bei der Diagnose von Alzheimer und der Auswahl von Teilnehmern f\u00fcr klinische Studien und die Krankheits\u00fcberwachung verbessern\u201c, sagte Karikari, berichtete die Verkaufsstelle.<\/p>\n<p>Obwohl aktuelle Bluttests abnormale Mengen an Amyloid- und Tau-Proteinen nachweisen k\u00f6nnen, hat es sich als schwierig erwiesen, hirnspezifische Marker f\u00fcr Nervenzellsch\u00e4den zu erkennen. Hier unterscheidet sich der von Karikari und seinem Team entwickelte Bluttest. Das Forschungsteam hat einen auf Antik\u00f6rpern basierenden Bluttest entwickelt, der eine bestimmte Form des Tau-Proteins, das sogenannte aus dem Gehirn stammende Tau, nachweist. Dieses Protein ist spezifisch f\u00fcr die Alzheimer-Krankheit.<\/p>\n<p>F\u00fcr die Studie testeten die Forscher 600 Patienten, die an unterschiedlichen Stadien der Alzheimer-Krankheit litten. Sie fanden heraus, dass der Tau-Spiegel im Gehirn dem Tau-Spiegel im Liquor entsprach. Au\u00dferdem k\u00f6nnte der Bluttest Alzheimer von anderen neurodegenerativen Erkrankungen unterscheiden.<\/p>\n<p>Die Proteinwerte zeigten auch einen starken Zusammenhang mit der Schwere von Amyloid-Plaques und Tau-Verwicklungen im Gehirngewebe von an Alzheimer verstorbenen Menschen, so die Studie.<\/p>\n<p>Karikari hoffte, dass die \u00dcberwachung des Tau-Spiegels im Blut aus dem Gehirn dazu beitragen k\u00f6nnte, effiziente klinische Studien f\u00fcr Alzheimer-Behandlungen zu entwickeln.<\/p>\n<p>Das hat eine separate Studie herausgefunden <a href=\"https:\/\/www.medicaldaily.com\/study-finds-multiple-rare-damaging-genetic-variants-increase-alzheimers-risk-467528\">seltene, sch\u00e4dliche genetische Varianten<\/a> die das Risiko einer Alzheimer-Erkrankung erh\u00f6hen.<\/p>\n<p>\u201eUnsere Ergebnisse liefern zus\u00e4tzliche Beweise f\u00fcr eine wichtige Rolle der Amyloid-\u03b2-Vorl\u00e4uferproteinverarbeitung, der Amyloid-\u03b2-Aggregation, dem Lipidstoffwechsel und der Mikrogliafunktion bei AD\u201c, schreiben die Autoren in ihrer Arbeit.<\/p>\n<p>Mithilfe einer genbasierten Belastungsanalyse anstelle der h\u00e4ufigeren genomweiten Assoziationsstudien (GWAS) fanden die Forscher einen starken Zusammenhang zwischen seltenen, sch\u00e4dlichen Varianten in ATP8B4 und ABCA1 mit AD-Risiko und einem Signal in ADAM10 sowie selten -Variantenlast in den Genen RIN3, CLU, ZCWPW1 und ACE, laut GenEngNews.<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/scientists-develop-blood-test-alzheimers-diagnosis-467657?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>\u201eEin Bluttest ist kosteng\u00fcnstiger, sicherer und einfacher durchzuf\u00fchren und kann das klinische Vertrauen bei der Diagnose von Alzheimer und der Auswahl von Teilnehmern f\u00fcr klinische Studien und die Krankheits\u00fcberwachung verbessern\u201c, sagte Prof. Thomas Karikari.<\/p>","protected":false},"author":2,"featured_media":7082,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/scientists-develop-blood-test-for-alzheimers-diagnosis.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7081","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Scientists Develop Blood Test For Alzheimer&#039;s Diagnosis - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/urbancare.clinic\/de\/wissenschaftler-entwickeln-bluttest-zur-alzheimer-diagnose\/\" 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