{"id":7051,"date":"2022-12-23T12:51:18","date_gmt":"2022-12-23T09:51:18","guid":{"rendered":"https:\/\/www.medicaldaily.com\/common-acne-treatment-adolescents-can-have-long-term-effects-skeletal-system-467625"},"modified":"2022-12-23T12:51:18","modified_gmt":"2022-12-23T09:51:18","slug":"haufige-aknebehandlungen-bei-jugendlichen-konnen-langfristige-auswirkungen-auf-die-studie-des-skelettsystems-haben","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study\/","title":{"rendered":"H\u00e4ufige Aknebehandlung bei Jugendlichen kann langfristige Auswirkungen auf das Skelettsystem haben: Studie"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study.jpg\" class=\"ff-og-image-inserted\" style=\"display:none\"><\/div>\n<p>Jugendliche mit Akne m\u00fcssen m\u00f6glicherweise zweimal dar\u00fcber nachdenken, bevor sie eine \u00fcbliche Antibiotikabehandlung zur L\u00f6sung von Hautproblemen beginnen. Eine neue Studie hat ergeben, dass eine Antibiotikabehandlung das Skelettsystem nachhaltig ver\u00e4ndern kann.<\/p>\n<p>Die Studie, ver\u00f6ffentlicht in der&nbsp;<a href=\"https:\/\/insight.jci.org\/articles\/view\/160578\" rel=\"nofollow noopener\" target=\"_blank\">Einblicke in das Journal of Clinical Investigation (JCI).<\/a>zeigten, dass die langfristige topische Anwendung eines systemischen Antibiotikums, Minocyclin, unbeabsichtigte Auswirkungen auf die Knochenentwicklung bei Jugendlichen haben kann.<\/p>\n<p>Die Behandlung mit Minocyclin kann bis zu zwei Jahre dauern. Dieses Antibiotikum ver\u00e4ndert das Darmmikrobiom \u2013 die Population der im Darm lebenden Mikroorganismen.<\/p>\n<p>Forscher der Medical University of South Carolina (MUSC) fanden einen starken Zusammenhang zwischen der Zusammensetzung des Darmmikrobioms und einer gesunden Skelettreifung.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>F\u00fcr die Studie verabreichte das Forschungsteam M\u00e4usen w\u00e4hrend der pubert\u00e4ren\/postpubert\u00e4ren Wachstumsphase, die dem Jugendalter beim Menschen entspricht, eine angemessene Dosis Minocyclin.<\/p>\n<p>In der Studie wurde festgestellt, dass die Minocyclin-Therapie zwar keine zytotoxischen Wirkungen hervorrief oder eine entz\u00fcndungsf\u00f6rdernde Reaktion hervorrief, jedoch die Zusammensetzung des Darmmikrobioms ver\u00e4nderte, was zu einer verringerten Ansammlung von Knochenmasse und einer ineffizienten Skelettreifung f\u00fchrte.<\/p>\n<p>\u201eNach einer langfristigen systemischen Minocyclin-Therapie kommt es zu anhaltenden Ver\u00e4nderungen im Darmmikrobiom, die zu einer verringerten Knochenreifung f\u00fchren\u201c, berichtete Erstautor Matthew Carson vom Novince-Labor&nbsp;<a href=\"https:\/\/scitechdaily.com\/common-acne-treatment-can-have-unintended-life-long-effects-on-the-skeleton\/\" rel=\"nofollow noopener\" target=\"_blank\">SciTechDaily<\/a>.<\/p>\n<p>\u201eAus klinischer Sicht f\u00fchrt die Behandlung mit Minocyclin nicht nur zu Ver\u00e4nderungen des reifenden Skeletts, auch das Mikrobiom und das Skelett k\u00f6nnen sich nach einer Antibiotikatherapie nicht vollst\u00e4ndig erholen\u201c, sagt Chad Novince, Hauptforscher und au\u00dferordentlicher Professor in der Abteilung f\u00fcr Mundgesundheitswissenschaften im College of Dental Medicine hinzugef\u00fcgt.<\/p>\n<p>Minocyclin geh\u00f6rt zur Antibiotikaklasse der Tetracycline. Zu dieser Gruppe geh\u00f6ren auch Antibiotika wie Tetracyclin, Doxycyclin und Sarecyclin. Diese Antibiotika hemmen das Wachstum und die Ausbreitung von Bakterien. Im Fall von&nbsp;<a href=\"https:\/\/www.ibtimes.com\/researchers-uncover-renaissance-beauty-secrets-3602246\" rel=\"nofollow noopener\" target=\"_blank\">Akne<\/a>Sie t\u00f6ten die Bakterien ab, die die Poren infizieren, und reduzieren bestimmte Akne verursachende nat\u00fcrliche \u00f6lige Substanzen.<\/p>\n<p>\u201eWas wirklich interessant ist, ist, dass wenn Sie in dieser Jugendphase, in der sich Ihre Mikrobiota noch in Richtung eines stabilen Erwachsenenstadiums entwickelt, Ver\u00e4nderungen am Mikrobiom herbeif\u00fchren, dies tiefgreifende Auswirkungen auf das heranreifende Skelett haben wird\u201c, sagte Carson laut der Verkaufsstelle.<\/p>\n<p>Interessanterweise stellte das Team fest, dass die durch Minocyclin verursachten Ver\u00e4nderungen im Darmmikrobiom auch die Kommunikation zwischen der Leber und dem D\u00fcnndarm beeinflussten, die \u00fcber Molek\u00fcle namens Gallens\u00e4uren erfolgt.<\/p>\n<p>\u201eGallens\u00e4uren galten bisher nicht als wichtige Kommunikationsmolek\u00fcle zwischen Darm und Skelett\u201c, sagte Novince der Zeitung zufolge. \u201eDurch die Ver\u00e4nderung des Darmmikrobioms ver\u00e4ndert sich die Zusammensetzung der Gallens\u00e4uren, was sich auf die Physiologie des Wirts, einschlie\u00dflich der Skelettreifung, auswirkt.\u201c<\/p>\n<p>Das ver\u00e4nderte Darmmikrobiom schuf einen anderen Pool an Gallens\u00e4uren. Diese verschiedenen Arten von Gallens\u00e4uren konnten knochenbildende Zellen, sogenannte Osteoblasten, nicht aktivieren, was wiederum die Knochenbildung und -mineralisierung um mehr als 30% verringerte.<\/p>\n<p>\u201eDas war wirklich kollaborative Wissenschaft, und ich denke, dass wir heute dabei sind\u201c, sagte Novince. \u201eUm wirkungsvolle Wissenschaft voranzutreiben, m\u00fcssen Experten aus verschiedenen Berufen und Disziplinen hinzugezogen werden. Wir hatten das Gl\u00fcck, ein wirklich starkes Team zu haben. Es hat Spa\u00df gemacht \u2013 das Ganze war spannend!\u201c<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/common-acne-treatment-adolescents-can-have-long-term-effects-skeletal-system-467625?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>In der Studie wurde festgestellt, dass die Minocyclin-Therapie die Zusammensetzung des Darmmikrobioms ver\u00e4nderte, was zu einer geringeren Ansammlung von Knochenmasse und einer ineffizienten Skelettreifung f\u00fchrte.<\/p>","protected":false},"author":2,"featured_media":7052,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"Default","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/common-acne-treatment-in-adolescents-can-have-long-term-effects-on-skeletal-system-study.jpg","fifu_image_alt":"","footnotes":""},"categories":[27],"tags":[],"class_list":["post-7051","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Common Acne Treatment In Adolescents Can Have Long-Term Effects On Skeletal System: Study - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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