{"id":7021,"date":"2022-12-22T13:03:40","date_gmt":"2022-12-22T10:03:40","guid":{"rendered":"https:\/\/www.medicaldaily.com\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-467615"},"modified":"2022-12-22T14:43:03","modified_gmt":"2022-12-22T11:43:03","slug":"studienergebnisse-zeigen-dass-6-neurogenerative-krankheiten-gemeinsame-und-einzigartige-zellulare-wegweiser-haben","status":"publish","type":"post","link":"https:\/\/urbancare.clinic\/de\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds\/","title":{"rendered":"6 Neuroregenerative Erkrankungen haben gemeinsame und einzigartige zellul\u00e4re Wegweiser, wie Studienergebnisse zeigen"},"content":{"rendered":"<div><img decoding=\"async\" src=\"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds.jpg\" class=\"ff-og-image-inserted\"  style=\"display:none\"><\/div>\n<p>Eine Studie ergab, dass mehrere neurodegenerative Erkrankungen gemeinsame und einzigartige dysfunktionale zellul\u00e4re Prozesse aufweisen.<\/p>\n<p>Zu den sechs neurodegenerativen Erkrankungen, bei denen diese Gemeinsamkeit auftrat, geh\u00f6ren Amyotrophe Lateralsklerose oder Lou-Gehrig-Krankheit, Alzheimer-Krankheit, Friedreich-Ataxie, frontotemporale Demenz, Huntington-Krankheit und Parkinson-Krankheit.<\/p>\n<p>F\u00fcr die Studie, ver\u00f6ffentlicht in&nbsp;<a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/alz.12880\" rel=\"nofollow noopener\" target=\"_blank\">Alzheimer und Demenz: Das Journal der Alzheimer&#039;s Association<\/a><em><a href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/alz.12880\" rel=\"nofollow noopener\" target=\"_blank\">,<\/a>&nbsp;<\/em>Die Forscher setzten maschinelle Lernanalysen von RNA aus Blutproben ein. Die Blutproben wurden einer \u00f6ffentlich zug\u00e4nglichen Datenbank namens Gene Expression Omnibus entnommen. Anschlie\u00dfend verglich das Forschungsteam mehrere Krankheiten, um RNA-Marker zu identifizieren, die bei mehreren neurodegenerativen Erkrankungen auftreten und die f\u00fcr jede Erkrankung einzigartig sind.<\/p>\n<p>Die Studie fand acht Gemeinsamkeiten bei sechs neurodegenerativen Erkrankungen. Dabei handelt es sich um Transkriptionsregulation, Degranulation (verbunden mit Entz\u00fcndungsprozessen), Immunantwort, Proteinsynthese, Zelltod oder Apoptose, Zytoskelettkomponenten, Ubiquitylierung\/Proteasom (Teil des Proteinabbaus) und mitochondriale Komplexe (\u00fcberwachen den Energieverbrauch in Zellen). <a href=\"https:\/\/www.news-medical.net\/news\/20221221\/Study-explores-cellular-alterations-in-six-distinct-neurodegenerative-diseases.aspx?showform=cookiesettings\" rel=\"nofollow noopener\" target=\"_blank\">NachrichtenMedizin<\/a>.<\/p>\n<div id=\"dfp-ad-oop2\" class=\"dfp-tag-wrapper\"> <\/div>\n<p>Diese acht zellul\u00e4ren Funktionsst\u00f6rungen sind mit identifizierbaren Pathologien im Gehirn f\u00fcr jede Krankheit verbunden. Neben diesen acht fand die Studie auch einzigartige Marker f\u00fcr jede Krankheit.<\/p>\n<p>Beispielsweise wurden Transkripte im Zusammenhang mit einem Prozess namens Splei\u00dfosomenregulation entdeckt <a href=\"https:\/\/www.medicaldaily.com\/study-finds-multiple-rare-damaging-genetic-variants-increase-alzheimers-risk-467528\">Alzheimer-Erkrankung.<\/a><\/p>\n<p>\u201eEs scheint, dass mehrere neurodegenerative Erkrankungen \u00e4hnliche grundlegende dysfunktionale zellul\u00e4re Prozesse aufweisen. Unterschiede zwischen Krankheiten k\u00f6nnen der Schl\u00fcssel zur Entdeckung regionaler Zelltyp-Schwachstellen und therapeutischer Ziele f\u00fcr jede Krankheit sein\u201c, sagte die Erstautorin der Studie, Carol Huseby, Forscherin am ASU-Banner Neurodegenerative Disease Research Center, berichtete die Verkaufsstelle.<\/p>\n<p>Nach Angaben der Vereinten Nationen k\u00f6nnte die weltweite Zahl der Todesopfer durch alle neurodegenerativen Erkrankungen zusammengenommen bei einer Milliarde Menschen liegen.<\/p>\n<p>Vor diesem Hintergrund ist der Bedarf an neuartigen Methoden zur Fr\u00fchdiagnose, besseren Behandlungen und sogar Methoden zur Pr\u00e4vention von gr\u00f6\u00dfter Bedeutung.<\/p>\n<p>Die aus dem Blut extrahierten RNA-Transkripte werden dem maschinellen Lernalgorithmus, bekannt als Random Forest, zugef\u00fchrt, der dann die Daten analysiert und die Ergebnisse mit bekannten Mustern vergleicht, die mit krankheitsbedingten biologischen Signalwegen verbunden sind.<\/p>\n<p>\u00dcbliche andere Testformen sind oft weniger detailliert, teuer, invasiv und arbeitsintensiv. Im Gegensatz dazu ist die Vollblutdiagnostik eine kosteng\u00fcnstige Alternative. Es kann problemlos bei Patienten in allen Lebensphasen gesammelt werden.<\/p>\n<p>Dar\u00fcber hinaus k\u00f6nnen Ver\u00e4nderungen im Blutergebnis verfolgt werden, was dabei helfen kann, den Krankheitsverlauf zu verfolgen.<\/p>\n<p>Die Studie er\u00f6ffnet die M\u00f6glichkeit, dass sich RNA-Ver\u00e4nderungen, die bei mehreren Krankheiten auftreten, sp\u00e4ter zu einzelnen neurodegenerativen Erkrankungen entwickeln k\u00f6nnen. Der Mechanismus hinter diesem Ph\u00e4nomen bleibt jedoch ein R\u00e4tsel.<\/p>\n<p><a href=\"https:\/\/www.medicaldaily.com\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-467615?utm_source=Public&#038;utm_medium=Feed&#038;utm_campaign=Distribution\">Medizinische t\u00e4gliche Quelle<\/a><\/p>\n<p>","protected":false},"excerpt":{"rendered":"<p>Nach Angaben der Vereinten Nationen k\u00f6nnte die weltweite Zahl der Todesopfer durch alle neurodegenerativen Erkrankungen zusammengenommen bei einer Milliarde Menschen liegen.<\/p>","protected":false},"author":2,"featured_media":7022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"page_builder":"","fifu_image_url":"https:\/\/urbancare.clinic\/wp-content\/uploads\/2022\/12\/6-neurogenerative-diseases-have-common-and-unique-cellular-signposts-study-finds.jpg","fifu_image_alt":"","footnotes":""},"categories":[121],"tags":[],"class_list":["post-7021","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-articles"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>6 Neurogenerative Diseases Have Common And Unique Cellular Signposts, Study Finds - Urban Care Clinic<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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